Mood
Mood compounds work on stress resilience, anxiety reduction, and emotional baseline — they are not antidepressants in the clinical sense. The best options are adaptogens (HPA-axis modulation, cortisol reduction), GABAergic (direct calming, sedation risk), or monoamine precursors (dopamine and serotonin support).
Top compounds
| Compound | Rank | Score | Cost | Target | Speed |
|---|---|---|---|---|---|
| Sleep | — | 9/10 | Free | adaptogenic | long term |
| Saffron | — | 9/10 | Mid | adaptogenic | medium |
| LSD | — | 9/10 | — | adaptogenic | long term |
| Psilocybin | — | 9/10 | — | adaptogenic | long term |
| Exercise | — | 8/10 | Free | adaptogenic | long term |
| Mucuna Pruriens | — | 8/10 | Budget | monoamine precursors | acute |
| St. Johns Wort | — | 8/10 | Budget | adaptogenic | medium |
| Phenibut | — | 8/10 | Mid | GABAergic | acute |
| Diet | — | 7/10 | Free | adaptogenic | long term |
| 5-HTP | — | 7/10 | Budget | adaptogenic | acute |
| Ashwagandha | — | 7/10 | Budget | adaptogenic | medium |
| CBD | — | 7/10 | Mid | adaptogenic | acute |
| Kava | — | 7/10 | Mid | GABAergic | acute |
| Lithium | — | 7/10 | Budget | adaptogenic | medium |
| Vitamin D | — | 7/10 | Budget | monoamine precursors | medium |
| Aniracetam | — | 7/10 | Budget | monoamine precursors | acute |
| Bromantane | — | 7/10 | — | adaptogenic | medium |
| NSI-189 | — | 7/10 | — | adaptogenic | long term |
| PE-22-28 | — | 7/10 | — | adaptogenic | long term |
| Selank | — | 7/10 | — | adaptogenic | acute |